I find the concept of creation “groaning” interesting in Book IX after the fall:
In pangs, and Nature gave a second groan,
Skie lowr’d, and muttering Thunder, som sad drops
Wept at compleating of the mortal Sin (1001 – 1003)
Both Adam and Eve’s choice to “eat of death” obviously had serious spiritual ramifications but cannot be removed from the very physical action of consuming the fruit nor the consequence of physical death, which in return is not isolated to only them but all creation. This appears to be referring to Romans 8:19-23 where Paul writes,
For the creation waits with eager longing for the revealing of the sons of God. For the creation was subjected to futility, not willingly, but because of him who subjected it, in hope that the creation itself will be set free from its bondage to corruption and obtain the freedom of the glory of the children of God. For we know that the whole creation has been groaning together in the pains of childbirth until now.
The fall, in this context, is the point at which the earth becomes subject to decay. This simple personification of Paradise and the rest of the created realm groaning in physical pain because of original sin somehow amplifies the significance of what has just happened beyond the spiritual implications.